Project Detail
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Neuroligin regulation of central GABAergic synapses  

Synapse formation and maturation are crucial processes in the generation of neuronal circuits in the brain, and aberrant synapse development may lead to neurodevelopmental disorders such as autism. The role of neuroligins (NLs – postsynaptic cell adhesion molecules) in synapse formation may be more expansive than previously thought. This study uses biochemical methods in cultured cells to determine if a specific NL (NL2) facilitates GABAergic synapse formation and accelerates synaptic transmission by recruiting a particular type of GABAA receptor. Determining the function of neuroligins at inhibitory synapses will increase our ability to develop more effective diagnosis and treatment methods for neurodevelopmental disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $78,000.00
Project Number 1R03MH085224-01
Principal Investigator Fu, Zhanyan
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Duke University
State/Country North Carolina
Web Link 1 Neuroligin regulation of central GABAergic synapses (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neuroligin regulation of central GABAergic synapses | $78,000.00 | 2010 | 5R03MH085224-02