Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Mouse models of the neuropathology of tuberous sclerosis complex  

Tuberous sclerosis complex (TSC) is genetic disorder affecting approximately 1/6000 individuals, causing brain lesions that are associated with seizures, autism, and other developmental disabilities. Remarkably, little is known about the pathogenesis of these lesions or how they lead to developmental disabilities. The goal of this research project is to use mouse genetics to understand the developmental abnormalities that lead to the brain lesions of the genetic disease tuberous sclerosis complex (TSC). Well characterized models will establish a foundation for the testing of future targeted therapies and establish developmental neurobiologic differences between subsets of patients with TSC. Project Status


Funder National Institutes of Health
Fiscal Year Funding $258,344.00
Project Number 5R01NS060804-03
Principal Investigator Gambello, Michael
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of Texas Health Science Center at Houston
State/Country Texas
Web Link 1 Mouse models of the neuropathology of tuberous sclerosis complex (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Mouse models of the neuropathology of Tuberous Sclerosis Complex | $258,136.00 | 2008 | R01NS060804-02