Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Uncovering genetic mechanisms of ASD  

Gene expression, or messenger RNA (mRNA) profiling, has been used successfully in cancer research to help characterize and categorize different types of neoplasia and predict such behaviors as responsiveness to treatment and likelihood of metastasis. Dr. Kunkel and colleagues plan to use expression profiling to explore the possibility of establishing "signatures" of gene expression that could distinguish individuals with autism from controls. In addition, he intends to examine splicing patterns of neuronal mRNA that could lead to pathogenesis to explore a possible mechanistic link with observed copy number variants (CNV). Project Status


Funder Autism Speaks
Fiscal Year Funding $150,000.00
Project Number 1968
Principal Investigator Kunkel, Louis
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 Uncovering genetic mechanisms of ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Uncovering genetic mechanisms of ASD | $127,500.00 | 2010 | 1968
Uncovering genetic mechanisms of ASD | $150,000.00 | 2008 | 1968