Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Network: A comprehensive approach to identification of autism susceptibility genes  

This study is part of an Autism Centers of Excellence (ACE) Network. Although autism spectrum disorders (ASD) have a multifactorial etiology they have a large genetic component. It is also becoming clear that comprehensive efforts involving large sample sizes and methods to reduce heterogeneity are necessary to achieve maximal power to identify disease critical regions narrow enough to permit positional cloning of autism susceptibility genes. The investigators in this application aim to continue their collaborative effort that has produced and enhanced a highly successful open data and biomaterials resource for the research community, the Autism Genetic Resource Exchange (AGRE). This collaborative network application, involving six research sites and the AGRE DCC, will systematically and comprehensively investigate the genetics of ASD to identify rare mutations, chromosomal abnormalities, and common variation contributing to ASD susceptibility. The investigators will then perform follow up linkage studies to confirm several new loci identified based on autism-related endophenotypes or co-variants, such as language delay, sex, and head circumference. Genetic risk factors identified in the mostly white European sample will be tested for association in the African American sample to determine whether these cohorts share the same genetic risk factors. All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, including minority families, further enhancing the value of this resource to the community. Project Status


Funder National Institutes of Health
Fiscal Year Funding $2,895,517.00
Project Number 5R01MH081754-02
Principal Investigator Geschwind, Daniel
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of California, Los Angeles
State/Country California
Web Link 1 ACE Network: A comprehensive approach to identification of autism susceptibility genes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects ACE Network: A comprehensive approach to identification of autism susceptibility genes | $2,823,814.00 | 2010 | 5R01MH081754-03