Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neurogenetics of candidate systems in autism (supplement)  

Numerous studies have demonstrated that genes are a major component of the etiology of autism, but these genes remain unidentified. Instead of using whole genome screens, this study develops a set of functional candidate genes based on knowledge of the specific behavioral deficits observed in individuals with autism and what is known about the neurobiology underlying those behaviors. Specifically, genes in the neurotransmitter systems utilizing serotonin and GABA will be analyzed in 600 families. Variations in each gene, called single nucleotide polymorphisms (SNPs), will be characterized, and the effects of interactions between the genes will be examined. This approach could discern the roles of serotonin and GABA genes in autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $23,730.00
Project Number 3P01NS026630-20S1
Principal Investigator Haines, Jonathan
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution Duke University
State/Country North Carolina
Web Link 1 Neurogenetics of candidate systems in autism (supplement) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neurogenetics of candidate systems in autism | $239,402.00 | 2008 | P01NS026630-20