Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Fundamental mechanisms of GPR56 activation and regulation  

Abnormalities in the development of the cerebral cortex can lead to a range of distinct neurodevelopmental disorders, including autism and Asperger's syndrome. To shed light on the factors that contribute to such diseases, the researchers will perform molecular analyses on cultured cells and cortical neurons to study the fundamental properties of the orphan receptor GPR56, which is believed to play a key role in cortical development since mutations in GPR56 cause a rare genetic disorder in which the development of the cerebral cortex is grossly distorted. Knowledge gained from these studies focused on the normal function of GPR56 will provide fresh insights into the role of GPR56 in human disease and also into the fundamental mechanisms that regulate the development of the cerebral cortex. Project Status


Funder National Institutes of Health
Fiscal Year Funding $135,625.00
Project Number 1R21NS063029-01A1
Principal Investigator Hall, Randy
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 Fundamental mechanisms of GPR56 activation and regulation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Fundamental mechanisms of GPR56 activation and regulation | $134,269.00 | 2010 | 5R21NS063029-02