Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A neuroimaging study of twin pairs with autism  

The proposed study will build on an ongoing NIMH-funded study (R01 MH 067005 "A population-based twin study of autism in California" PI: Joachim Hallmayer). The existence of this population-based study of twins, with at least one twin with autism, will provide unprecedented opportunities to examine the relative impact of genetic and nongenetic factors on brain anatomy and chemistry in autism. Specifically, 80 same-sex autism twin pairs comprised of 40 monozygotic (identical) and 40 dizygotic (fraternal) twin pairs, will be randomly recruited from the ongoing study. These twin pairs will be compared to 40 group-matched typically developing same-sex twin pair controls (20 monozygotic and 20 dizygotic). Experimental measures include high resolution anatomical brain scans, cognitive and behavioral measures, and neurochemical measures. The overarching goal is to understand how clinical features of autism may be linked to neurobiological measures in autistic individuals, thus allowing the identification of clinical or biological endophenotypes that will lead to a better characterization and understanding of this disorder. Project Status


Funder National Institutes of Health
Fiscal Year Funding $626,552.00
Project Number 1R01MH083972-01A1
Principal Investigator Hardan, Antonio
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 A neuroimaging study of twin pairs with autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects A neuroimaging study of twin pairs with autism | $632,389.00 | 2010 | 5R01MH083972-02