Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Social behavior deficits in autism: Role of amygdala  

The model researchers propose to examine (prenatal exposure to sodium valproate) has been shown by others to result in changes in social and other behaviors that are similar to those seen in people with autism. The study will focus on the biology, that is, to determine what changes in the brain underlie the behavioral deficits. Data generated during this study will add to the understanding of how changes in the brain contribute to social behavior. Determining exactly which brain regions underlie the social behavior deficits will allow clinicians to focus on imaging those specific parts of the brain to diagnose autism, and early and accurate diagnosis improves prognosis. Understanding the regions of the brain important for social behavior, and how changes in the gene expression, structure, and function of those regions affect social behavior, will provide novel targets for therapeutic interventions, such as oxytocin. Finally, understanding which particular times of pregnancy the developing brain is especially vulnerable will allow physicians to better manage care of their patients, as well as allowing them to inform their patients regarding the risks associated with taking drugs at those times. Project Status


Funder Autism Speaks
Fiscal Year Funding $93,500.00
Project Number 4946
Principal Investigator Mooney, Sandra
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution State University of New York Upstate Medical Center
State/Country New York
Web Link 1 Social behavior deficits in autism: Role of amygdala (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Social behavior deficits in autism: Role of amygdala | $110,000.00 | 2008 | 4946
Social behavior deficits in autism: Role of amygdala | $79,438.00 | 2010 | 4946