Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Multimodal neuroimaging of white matter in autism  

Large brains are common in autism, but their underlying tissue microstructure and their impact on the autistic phenotype are not understood. This research is based on the model that increased white matter volume is related to impaired connectivity and to underlying core processing abnormalities in autism. This model will be tested by pursuing prior findings that white matter enlargement drives large brains and is localized to the white matter closest to the cerebral cortex. Multispectral magnetic resonance imaging (MRI) will be used to gain systematic information about the tissue microstructure and patterns of structural connectivity of enlarged white matter in autism, and these findings will be related to cognitive and behavioral phenotypes and to genome data. Project Status


Funder National Institutes of Health
Fiscal Year Funding $472,805.00
Project Number 5R01NS048455-04
Principal Investigator Herbert, Martha
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Massachusetts General Hospital
State/Country Massachusetts
Web Link 1 Multimodal neuroimaging of white matter in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Multimodal neuroimaging of white matter in autism | $698,987.00 | 2008 | R01NS048455-03