Maternal infection in animals is a model to study the deleterious effects of immune challenge during pregnancy on early brain development and subsequent adolescent and adult behavior, cognition, and mood. Early exposure to an immune challenge can result in developmental disturbances with long-term consequences, including autism. This study uses the maternal immune activation (MIA) model in rats to study disorders with early neurodevelopmental etiology, such as schizophrenia, autism, and anxiety disorder. The study will subject pregnant rats to an immune challenge (LPS administration), and the offspring will be studied for behavioral alterations (like social deficits that mirror autism and cognitive deficits that mirror schizophrenia) and their underlying biochemical causes. Studying the biological changes underlying these behavioral changes will further understanding of the etiology and pathogenesis of these and other diseases.