Project Detail
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Studies of central nervous system functional anatomy  

Maternal infection in animals is a model to study the deleterious effects of immune challenge during pregnancy on early brain development and subsequent adolescent and adult behavior, cognition, and mood. Early exposure to an immune challenge can result in developmental disturbances with long-term consequences, including autism. This study uses the maternal immune activation (MIA) model in rats to study disorders with early neurodevelopmental etiology, such as schizophrenia, autism, and anxiety disorder. The study will subject pregnant rats to an immune challenge (LPS administration), and the offspring will be studied for behavioral alterations (like social deficits that mirror autism and cognitive deficits that mirror schizophrenia) and their underlying biochemical causes. Studying the biological changes underlying these behavioral changes will further understanding of the etiology and pathogenesis of these and other diseases. Project Status


Funder National Institutes of Health
Fiscal Year Funding $1,340,580.00
Project Number 1ZIAMH001090-32
Principal Investigator Herkenham, Miles
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective 3O. Not specific to Question 3 objectives
Federal or Private? Federal
Institution National Institutes of Health (NIH)
State/Country Maryland
Web Link 1 Studies of central nervous system functional anatomy (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Studies of central nervous system functional anatomy | $1,048,141.00 | 2008 | Z01MH001090-31