Project Detail
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Project 1: Environmental epidemiology of autism  

The Epidemiology Project of the University of California-Davis Center for Children's Environmental Health (CCEH) will build upon its discovery of immunologic and molecular biomarkers specific to children with autism found in 2-5 year olds enrolled in the CHARGE (Childhood Autism Risks from Genetics and Environment) Study. As one of three interrelated research projects, this study will assess the stability of these immunologic markers over time. It will also test whether children with autism can be distinguished from those without autism by markers of immune dysregulation (at birth as well as post-diagnosis) and by prenatal, immunologically relevant events and exposures. The study aims to determine if children with and without autism differ with regard to exposures, body burdens, and excretion of xenobiotics, including metals, pesticides, and other pollutants (i.e., PBDE's). The transcriptional genomic profiles of children with and without autism will also be analyzed. Finally, a study tracking women at high risk for giving birth to a child with autism will follow them from early pregnancy until the child is three years old. The overall goal of the project is to determine early predictors of autism, whether they be immunologic, genomic, or environmental. Project Status


Funder National Institutes of Health
Fiscal Year Funding $213,876.00
Project Number 5P01ES011269-09
Principal Investigator Hertz-Picciotto, Irva
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3LC. Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Project 1: Environmental epidemiology of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Project 1: Environmental epidemiology of autism | $279,901.00 | 2010 | 5P01ES011269-10
Project 1: Environmental epidemiology of autism | $181,428.00 | 2008 | P01ES011269-08