Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genetics and physiology of social anxiety in fragile X  

This is a mentored Research Career Development Award to support the career development of clinical investigators in patient-oriented research. The research project includes measurement of biobehavioral markers of autonomic and amygdala function, fragile X mental retardation 1 (FMR1) mRNA and gene expression, and behavioral measures in children with fragile X and matched comparison samples of children with idiopathic developmental disability and typical development. The primary underlying hypothesis of the project is that the FMR1 mutation causes over-responsiveness of the amygdala to social stimuli, leading to symptoms of social anxiety and avoidance that are hallmark behavioral features of the fragile X behavioral phenotype. The study will also investigate whether this mechanism of increased anxiety contributes to autistic behaviors, particularly deficits in reciprocal social behavior, in children with fragile X. Project Status


Funder National Institutes of Health
Fiscal Year Funding $160,398.00
Project Number 5K23MH077554-05
Principal Investigator Hessl, David
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Genetics and physiology of social anxiety in fragile X (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Genetics and physiology of social anxiety in fragile X | $157,300.00 | 2008 | K23MH077554-04