Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neocortical regionalization: Analysis of genetic and epigenetic influences  

The human neocortex is comprised of many areas that perform high-level functions, ranging from basic sensory processes to cognitive thought. The organization of the neocortex and its connections forms a sophisticated system that generates human thought, perception, action, emotion, and cognition. Abnormalities in this system are the basis for many human developmental psychiatric disorders and syndromes. Most alterations occur developmentally during the time in which the neocortex is divided into discreet, functional areas; however, the mechanism of this regionalization is not well understood. The proposed research will use mice to directly examine the interactions of sensory input and gene expression and their influence on neocortical regionalization, as well as determine how these interactional influences vary by developmental maturity. Understanding the mechanisms involved in brain development will help the larger understanding of the causes of developmental disorders in children. Project Status


Funder National Institutes of Health
Fiscal Year Funding $75,000.00
Project Number 5R03MH080502-02
Principal Investigator Huffman, Kelly
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of California, Riverside
State/Country California
Web Link 1 Neocortical regionalization: Analysis of genetic and epigenetic influences (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neocortical regionalization: Analysis of genetic and epigenetic influences | $75,000.00 | 2008 | R03MH080502-01A1