Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autism: Neuropeptide hormones and potential pathway genes  

This is a mentored Research Career Development Award to support the career development of clinical investigators in patient-oriented research. The phenotypic differences in behavior and physiology observed in autism spectrum disorders (ASD) are likely due to multiple genes. This study examines children with ASD by focusing on clinical phenotype, neurochemical measures, and genetic associations of related neuropeptide hormones, including oxytocin (OT), which is currently under trial for ASD treatment. Using an existing sample of patients, the study will examine whether genes in the OT and vasopressin (AVP) systems are associated with autism overall and with specific phenotypic subgroups. A clinical study will also be conducted to test the hypothesis that phenotypic differences in oxytocin levels outside the brain are related to variation in specific OT pathway processing genes. The trial will assess 250 outpatient subjects with ASD, ages 5-18 years, with diagnostic assays, OT/AVP blood assays, and genetic pathway testing. Project Status


Funder National Institutes of Health
Fiscal Year Funding $185,897.00
Project Number 5K23MH082121-02
Principal Investigator Jacob, Suma
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution University of Illinois at Chicago
State/Country Illinois
Web Link 1 Autism: Neuropeptide hormones and potential pathway genes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Autism: Neuropeptide hormones and potential pathway genes | $184,353.00 | 2010 | 5K23MH082121-03
Autism: Neuropeptide hormones and potential pathway genes | $186,260.00 | 2008 | K23MH082121-01
Autism: Neuropeptide hormones and potential pathway genes (supplement) | $54,000.00 | 2010 | 3K23MH082121-03S1