Project Detail
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Understanding the cognitive impact of early life epilepsy  

There is clinical evidence that early life seizures may be one of many precedents for autism, and epilepsy is common in patients with autism, suggesting an interaction between the two processes. In this study, researchers will induce seizure activity in young rats in order to determine whether early life seizures lead to cognitive dysfunction similar to that observed in autism. The researchers will also test whether different drug interventions administered after the seizure can help lessen neuronal damage caused by seizures. This study may uncover crucial biological connections between epilepsy and autism and identify therapeutic agents that could one day be used to treat these overlapping conditions. Project Status


Funder National Institutes of Health
Fiscal Year Funding $845,000.00
Project Number 5DP1OD003347-03
Principal Investigator Jensen, Frances
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism including seizures/epilepsy, sleep disorders and familial autoimmune disorders by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 Understanding the cognitive impact of early life epilepsy (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Understanding the cognitive impact of early life epilepsy | $845,000.00 | 2010 | 5DP1OD003347-04
Understanding the cognitive impact of early life epilepsy | $845,000.00 | 2008 | DP1OD003347-02