Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genetic study of restricted repetitive behavior in autism spectrum disorders  

As one of the core features of ASDs, restricted repetitive behavior (RRB) frequently dominates the daily activities of affected children, interferes with opportunities to develop functional behaviors, and requires intervention and treatment. The objective of this study is to identify contributing genetic factors for abnormal repetitive behavior (such as flapping arms, lining up objects, peculiar fascination with odd objects, a very narrow restricted interest, and intolerance to changes of routines) among children with autism spectrum disorders (ASDs). Researchers will investigate whether genetic variations within the GABA and glutamate neurotransmission system play a role in the pathogenesis of RRB in children with ASDs. Using behavioral rating scales, medical histories, and parental input, researchers will measure the extent of RRBs in children with ASD (ages 6-18). Biomaterials from these children, like saliva and buccal swabs, will be used to genotype GABA and glutamate system-related genes, allowing researchers to correlate genetic variants with RRB behavioral measures. Positive findings may lead to a new insight as to early detection and treatment of this chronic and disabling condition. Project Status


Funder National Institutes of Health
Fiscal Year Funding $72,856.00
Project Number 5R03MH083673-02
Principal Investigator Kim, Soo-Jeong
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.
Federal or Private? Federal
Institution University of Florida
State/Country Florida
Web Link 1 Genetic study of restricted repetitive behavior in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Genetic study of restricted repetitive behavior in autism spectrum disorders | $72,907.00 | 2008 | R03MH083673-01