Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Slick and slack heteromers in neuronal excitability  

This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. Deficits in auditory networks have been proposed to underlie hypersensitivity to auditory stimuli and stereotypic movements in autistic individuals. The purpose of this proposal is to identify the role of sodium-activated potassium (KNa) channels in auditory neurons. KNa channels are activated by intracellular sodium and show only weak voltage dependence. While the two genes which encode these channels have been identified (named Slack and Slick), researchers do not fully understand how these gene products work together to regulate properties of the KNa channels. Experiments in this project will use molecular biology, electrophysiology and sodium imaging techniques to determine some of the factors that mediate the activation and function of KNa channels in auditory neurons. Increased understanding of auditory network properties and KNa channels could lead to therapeutic targets for auditory hypersensitivity in autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $53,354.00
Project Number 5F32DC008449-02
Principal Investigator Kronengold, Jack
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 Slick and slack heteromers in neuronal excitability (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Slick and Slack heteromers in neuronal excitability | $9,298.00 | 2010 | 5F32DC008449-03
Slick and slack heteromers in neuronal excitability | $51,278.00 | 2008 | F32DC008449-01A1