Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autism: The neural substrates of language in siblings  

The purpose of this National Research Service Award is to provide support to an individual for combined M.D./Ph.D. and other dual doctoral degree training. Autism is a developmental disorder with impairments in language and communication as primary diagnostic criteria. Family studies of children with autism have noted similar features, or a "broader phenotype," in some first-degree relatives, including impairments in language functioning. Recent imaging studies in children with autism have found structural abnormalities in language association cortex, white matter overgrowth in areas underlying language regions, and evidence of underconnectivity between brain regions critical for complex language. The hypothesis of this research is that abnormalities in language-related cortex and decreased structural integrity of white matter connecting these regions are heritable neurobiological markers of language impairment in autism, and the heritable nature of autism suggests that siblings of children with autism may also exhibit these abnormalities. The proposed studies will provide insight into the etiology of language impairment in autism and will help to define genetic subgroups based on neurobiological markers that will complement existing behavioral phenotypes. Project Status


Funder National Institutes of Health
Fiscal Year Funding $56,140.00
Project Number 5F30NS055511-04
Principal Investigator Lindgren, Kristen
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Boston University Medical Campus
State/Country Massachusetts
Web Link 1 Autism: The neural substrates of language in siblings (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Autism: The neural substrates of language in siblings | $56,955.00 | 2010 | 5F30NS055511-05
Autism: The neural substrates of language in siblings | $33,151.00 | 2008 | F30NS055511-03