Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Maternal immune activation, cytokines, and the pathogenesis of autism  

Although a wide range of environmental stimuli have been proposed to play a role in the pathogenesis of autism spectrum disorders (ASDs), many of these stimuli have in common the ability to alter immune function. Since cytokines mediate the immune response, are present in the developing brain, and regulate cortical plasticity and connectivity, factors that alter cytokines during development may lead to changes in synaptic connectivity that contribute to ASD. The goals of this proposal are to use a mouse model of maternal immune activation (MIA) to define the full complement of cytokines that are changed in specific regions of the central nervous system (CNS) of offspring at various postnatal ages following MIA and to determine the effects of those cytokines on connectivity and function in several cortical regions at the relevant postnatal ages. Project Status


Funder National Institutes of Health
Fiscal Year Funding $378,570.00
Project Number 1R01MH088879-01
Principal Investigator McAllister, A. Kimberley
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3LC. Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Maternal immune activation, cytokines, and the pathogenesis of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Maternal immune activation, cytokines, and the pathogenesis of autism | $382,588.00 | 2010 | 5R01MH088879-02