Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Understanding repetitive behavior in autism  

This grant provides support for an NIH Autism Center of Excellence (ACE). Repetitive behaviors form a core feature of autism spectrum disorders (ASD), but the understanding of the neural basis of stereotypy and repetitive behaviors in ASD and their treatment is limited. Recently, risperidone, an antipsychotic, was observed to robustly reduce stereotypic behaviors in a sample of children and adolescents with autism. The proposed study attempts to increase understanding of repetitive behaviors in ASD and its treatment by examining the changes in key neural circuits associated with risperidone treatment using functional magnetic resonance imaging (fMRI). The proposed clinical trial and study design provide a unique opportunity to study the biology of treatment response on the target of repetitive behaviors which could cast a broader light on the nature of brain dysfunction across these similar parallel distributed brain systems and their interactions. Project Status


Funder National Institutes of Health
Fiscal Year Funding $330,198.00
Project Number 5P50HD055784-03
Principal Investigator McCracken, James
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.
Federal or Private? Federal
Institution University of California, Los Angeles
State/Country California
Web Link 1 ACE Center: Understanding repetitive behavior in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects ACE Center: Understanding repetitive behavior in autism | $326,665.00 | 2010 | 5P50HD055784-04
ACE Center: Understanding repetitive behavior in autism (supplement) | $55,094.00 | 2009 | 3P50HD055784-03S1