Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Novel pharmacological strategies in autism  

Despite an improved ability to reduce the aggression, self-injurious behavior (SIB), and irritability that often occur with autism, existing drug treatments are associated with significant adverse effects. The first study involves an 8-week randomized double-blind, placebo-controlled trial of the novel antipsychotic drug aripiprazole for the short-term treatment of aggression, SIB, and irritability in children and adolescents (age 6-17 years) with autism. The second study is a pilot combination drug treatment study to determine if adding open-label D-cycloserine, a partial agonist at the N-methyI-D-aspartate (NMDA) subtype of glutamate receptor, to aripiprazole results in improved social behavior in subjects whose aggression, SIB, and irritability remain stable upon completion of the first study. The long-term objective of this application is to improve the pharmacotherapy of autism by developing safer and more efficacious novel drug treatment strategies. Project Status


Funder National Institutes of Health
Fiscal Year Funding $305,254.00
Project Number 5R01MH072964-05
Principal Investigator McDougle, Christopher
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:
  • Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years.
  • Three randomized controlled trials of interventions for school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years.
  • Three trials for adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.
Federal or Private? Federal
Institution Indiana University-Purdue University Indianapolis
State/Country Indiana
Web Link 1 Novel pharmacological strategies in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Novel pharmacological strategies in autism | $305,254.00 | 2008 | R01MH072964-04