Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Identification and functional assessment of autism susceptibility genes  

Although there is strong evidence of a genetic contribution to the cause of autism spectrum disorders (ASD), the isolation of specific causative genetic defects has been difficult. This project will use existing DNA and clinical data from the Autism Genetic Resource Exchange (AGRE) and National Institute of Mental Health (NIMH) repositories to search for ASD susceptibility genes. Genotype analysis, mapping of single nucleotide polymorphisms (changes in a single DNA codon), and linkage studies will be used to identify candidate genes. Post-mortem human tissue, neuronal cultures, and mouse models will then be used to assess whether associated alleles in different locations on the chromosome (haplotypes) functionally alter autism candidate genes. These experiments are expected to identify ASD-associated alleles for multiple genes, and the mouse models that are generated for some of the associated haplotypes can be used as future models for developmental, behavioral, and toxicological experiments. Project Status


Funder National Institutes of Health
Fiscal Year Funding $486,498.00
Project Number 5R01MH076624-05
Principal Investigator Millonig, James
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
State/Country New Jersey
Web Link 1 Identification and functional assessment of autism susceptibility genes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A