Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genomic resources for identifying genes regulating social behavior  

Understanding the genetic and neurobiological mechanisms underlying social behavior will provide insights into determining how these systems go wrong in individuals with developmental disorders including autism. Using a naturalistic animal model, this study will examine the genetic influences on social behavior using two different species of rodents called voles. One species, the prairie vole, forms strong social bonds, while the other, the meadow vole, does not. Previous research has suggested that the difference in this social behavior may be due to a "microsatellite" region of genetic material that is located outside the area which transcribes the gene for the peptide hormone receptor Arginine vasopressin receptor 1A (avpr1). The molecules on which this receptor works, called oxytocin and vasopressin, have been shown to regulate this social affiliative behavior. Therefore, these researchers will create markers for these microsatellites as well as establish different strains of voles which show differing levels of social behaviors. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $0.00
Project Number 2002
Principal Investigator Young, Larry
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Emory University
State/Country Georgia
Web Link 1 Genomic resources for identifying genes regulating social behavior (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Genomic resources for identifying genes regulating social behavior | $60,000.00 | 2010 | 2002
Genomic resources for identifying genes regulating social behavior | $60,000.00 | 2008 | 2002