Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Analysis of cortical circuits related to ASD gene candidates  

This project aims to develop an efficient way of studying, in rodents, the deficits in neural circuitry resulting from the perturbation of autism candidate genes. The investigators will disrupt the function of candidate autism genes and use a combination of in vitro and in vivo technologies to probe for circuit level effects. They will use this strategy to test a leading hypothesis about the circuit dysfunction underlying autism, namely that autism results in a functional imbalance between excitatory and inhibitory synaptic activity. Rat auditory cortex will be used as a model system. Sensory abnormalities, particularly in the auditory domain, are one of the characteristic signs of autism. The initial focus will be on the neuroligins, a candidate gene family implicated in autism. In summary, this project proposes to develop a general and efficient strategy for relating genetic and physiological dysfunction in rodent models of autism. Project Status


Funder Autism Speaks
Fiscal Year Funding $127,500.00
Project Number 2125
Principal Investigator Zador, Anthony
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Cold Spring Harbor Laboratory
State/Country New York
Web Link 1 Analysis of cortical circuits related to ASD gene candidates (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Analysis of cortical circuits related to ASD gene candidates | $0.00 | 2010 | 2125
Analysis of cortical circuits related to ASD gene candidates | $150,000.00 | 2008 | 2125