Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A preclinical model for determining the role of AVPR1A in autism spectrum disorders  

Numerous studies, including human genetic and animal model studies, have shown that the neuropeptide arginine vasopressin (AVP) and its receptor arginine vasopressin receptor 1A (AVPR1A) play an important role in regulating behaviors associated with autism spectrum disorders (ASD). Due to the interspecies differences in AVPR1A receptor pharmacology and expression between mice and humans, studies of this receptor in rodents offer limited translation to human studies. This project proposes that generating a mouse expressing only the human form of AVPR1A will provide a more relevant in vivo system in which we can better understand the biology of the human AVPR1A receptor, its role in modulating behaviors associated with ASDs and the relevance of preclinical therapeutics targeting the receptor. Project Status


Funder Autism Science Foundation
Fiscal Year Funding $30,000.00
Project Number Project number unavailable
Principal Investigator Charles, Rhonda
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Mount Sinai School of Medicine
State/Country New York
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects A preclinical model for determining the role of AVPR1A in autism spectrum disorders | $0.00 | 2010 | n/a