Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: The pharmacogenetics of treatment for insistence on sameness in autism  

This grant provides support for an NIH Autism Center of Excellence (ACE). Insistence on Sameness (IS) is a common feature of ASD, and IS has been hypothesized to be due to improper serotonin regulation in this population. Many patients with ASD and IS benefit from treatment with medications that affect serotonin, in particular the selective serotonin reuptake inhibitors (SSRIs); however, there is little information available about which particular IS symptoms respond to SSRIs or which patients might be better candidates based on the presenting symptoms or their genetic variation. Clinical response to selective serotonin reuptake inhibitors (escitalopram) and effect of genetic variation in the serotonin transporter/receptor genes (SLC6A4 and HTR2A) on Insistence on Sameness (IS) symptoms will be explored in this pharmacogenetic study. Project Status


Funder National Institutes of Health
Fiscal Year Funding $377,577.00
Project Number 5P50HD055751-03
Principal Investigator Owley, Thomas
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.
Federal or Private? Federal
Institution University of Illinois at Chicago
State/Country Illinois
Web Link 1 ACE Center: The pharmacogenetics of treatment for insistence on sameness in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A