Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular and genetic epidemiology of autism  

This project investigates the genetic causes of autism using new genomic technology combined with novel statistical methodology. Specifically, the research will: 1) Broaden recruitment of subjects from a previous study to include the full range of the autism spectrum disorder (ASD) phenotype and more parent-child trios for analysis, 2) Identify the gene on chromosome 19 that has been linked to autism in multiple studies, 3) Investigate a newly defined linkage to chromosome 12 in large extended multigenerational autism families, 4) Extend studies of the genes for gamma aminobutyric acid (GABA) receptor subunits, 5) Identify clinically homogeneous subsets of patients and families and use the refined dataset to fine map ASD chromosomal regions and in candidate gene analyses, and 6) Test for evidence of new gene/gene interactions to fully explain the spectrum of autism risk. Project Status


Funder National Institutes of Health
Fiscal Year Funding $1,211,372.00
Project Number 5R01MH080647-13
Principal Investigator Pericak-Vance, Margaret
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of Miami Miller School of Medicine
State/Country Florida
Web Link 1 Molecular and genetic epidemiology of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Molecular and genetic epidemiology of autism | $1,186,466.00 | 2010 | 5R01MH080647-14
Molecular and genetic epidemiology of autism | $1,166,487.00 | 2008 | R01MH080647-12