Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Investigation of the role of MET kinase in autism  

Several lines of evidence indicate that the neurons do not signal to each other properly in people with autism. Most genes linked to autism regulate synapse formation and activity, and the abnormal patterns of activity in autistic brains also suggest that neurons are not making the right connections with each other. Dr. Dawson and colleagues propose that the low expression of the MET receptor may impair synapse formation and the wiring of neurons in the brain, leading to the social, language, and behavioral deficits associated with autism. To test this hypothesis, the researchers first plan to measure the activity of the MET receptor in people with autism to confirm that reduced gene expression correlates with low signaling in the cell. They plan to then study what happens in cultured neurons that have reduced MET signaling. The researchers intend to investigate the specific mechanisms by which reduced MET signaling leads to disruptions in neuronal signaling, hoping to link particular proteins in the signaling pathway to processes that could become targets for autism therapy. Project Status


Funder Simons Foundation
Fiscal Year Funding $488,411.00
Project Number SFARI-07-11
Principal Investigator Dawson, Ted
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Johns Hopkins University School of Medicine
State/Country Maryland
Web Link 1 Investigation of the role of MET kinase in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Investigation of the role of MET kinase in autism | $366,308.25 | 2010 | SFARI-07-11
Investigation of the role of MET kinase in autism | $488,411.00 | 2008 | Project number unavailable
Investigation of the role of MET kinase in autism | $0.00 | 2011 | SFARI-07-11