Project Detail
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Office of Autism Research Coordination (OARC) logo

Functional genomic dissection of language-related disorders  

Simon Fisher and his colleagues are aiming to uncover the neural mechanisms of abnormal language development in children with autism by studying the key genetic pathways that can go awry in these disorders. Fisher and his colleagues previously identified FOXP2 as the first example of a gene linked to speech and language deficits. FOXP2 is also present in non-speaking animals, where it is important for brain circuits involved in learning sequences of muscle movements. FOXP2 functions by switching other genes on and off. Using FOXP2 as a molecular entry point, Fisher and colleagues aim to identify other genetic mechanisms contributing to language problems in autism and related disorders. The researchers will use state-of-the-art genomic methods to define the networks of genes downstream of FOXP2 in the brain, and to determine how mutations in FOXP2 disrupt these pathways. They plan to later assess whether the identified genes are associated with specific language impairment or autism in cohorts of affected children. Project Status


Funder Simons Foundation
Fiscal Year Funding $78,584.50
Project Number 137593
Principal Investigator Fisher, Simon
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution University of Oxford
State/Country United Kingdom
Web Link 1 Functional genomic dissection of language-related disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Functional genomic dissection of language-related disorders | $235,753.00 | 2010 | 137593
Functional genomic dissection of language-related disorders | $320,076.00 | 2011 | 137593