Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Isolation of autism susceptibility genes  

Although genome-wide linkage scans and association studies have provided some promising leads in identifying genes that contribute to autism, no clear links have been established. This study builds on genomic data gathered in cohorts of extended families in both Iceland and the U.S. in which one or more family members have an autism diagnosis. The genome-wide linkage scans in these cohorts have revealed a number of suggestive gene loci for autism or autism-related endophenotypes, including quantitative trait loci (QTLs). Although not necessarily genes themselves, QTLs are stretches of DNA that are closely linked to the genes that underlie a specific trait. This study will phenotype additional relatives in Iceland and the U.S. and analyze both cohorts in parallel, performing the same QTL analysis, followed by fine mapping and narrowing regions of shared linkage. The focus will be on the isolation of genes within loci that are supported in both populations. Project Status


Funder National Institutes of Health
Fiscal Year Funding $593,350.00
Project Number 5R01MH071425-04
Principal Investigator Stefansson, Kari
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution deCODE Genetics, Inc.
State/Country Iceland
Web Link 1 Isolation of autism susceptibility genes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Isolation of autism susceptibility genes | $580,668.00 | 2008 | R01MH071425-03