Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The role of CNTNAP2 in embryonic neural stem cell regulation  

Dr. Gaiano and his colleagues are examining the role of an autism-associated gene expressed during development of the neocortex — an area of the brain that controls the cognitive functions that are affected in people with the disorder. The gene, CNTNAP2, is thought to play a causal role in autism when mutated, and some common variants of the gene confer a greater risk of the disorder. To elucidate the gene's role, Gaiano's team will use several molecular methods. They will first track the expression of Cntnap2 in the neocortex of developing mouse embryos. They will then artificially enhance or block the gene's function in mouse embryos and observe the resulting changes in the growth and function of brain neurons after the mice are born. Project Status


Funder Simons Foundation
Fiscal Year Funding $75,000.00
Project Number 137807
Principal Investigator Gaiano, Nicholas
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Johns Hopkins University School of Medicine
State/Country Maryland
Web Link 1 The role of CNTNAP2 in embryonic neural stem cell regulation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The role of CNTNAP2 in embryonic neural stem cell regulation | $150,000.00 | 2010 | 137807