Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Unraveling the genetic etiology of autism  

Autism is a neuropsychiatric disorder exhibiting a complex genetic etiology with significant clinical and genetic heterogeneity. Autism predominantly affects males compared to females, leading to significant interest into the cause of this sex bias in disease risk or expression. This research will follow up on initial studies that implicate a network of gene loci critical for the development and regulation of the neurotransmitter serotonin in autism. The nature and extent of susceptibility associated with the serotonin (5-HT) transporter (SLC6A4) and integrin 33 (ITGB3) loci will be determined. These genes lie within a chromosome region that confers significant male-biased genetic risk in autism. This project will advance understanding of how genetic variation affects expression and function of proteins controlling development and interconnection of a vital neurotransmitter system that is implicated in the etiologies of autism and many other disorders. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $491,266.00
Project Number 5R01NS049261-04
Principal Investigator Sutcliffe, James
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution Vanderbilt University
State/Country Tennessee
Web Link 1 Unraveling the genetic etiology of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Unraveling the genetic etiology of autism | $500,900.00 | 2010 | 5R01NS049261-05
Unraveling the genetic etiology of autism | $485,467.00 | 2008 | R01NS049261-03