Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Biological correlates of altered brain growth in autism  

This project will develop lines of induced pluripotent stem cells (iPSC) from individuals with autism spectrum disorders (ASD) with macrocephaly and typically developing children, using cells obtained by a skin biopsy. Several iPSC lines per individual will be produced and characterized with respect to their biology and their structural genetic variation. The aim is create a resource and analytical tool, which will enable examination of neuronal differentiation in autism spectrum disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $1,011,793.00
Project Number 1R01MH089176-01
Principal Investigator Vaccarino, Flora
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 Biological correlates of altered brain growth in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Biological correlates of altered brain growth in autism | $975,783.00 | 2010 | 5R01MH089176-02