Project Detail
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Morphogenesis and function of the cerebral cortex  

Abnormalities in the development of the prefrontal cortex are thought to underlie the symptoms of schizophrenia, autism, attention deficit hyperactivity, and drug addiction. This study uses cell systems to investigate how growth factors of the fibroblast growth factor (FGF) family establish the primary structure of the cerebral cortex by controlling the genesis of cortical projection neurons from subventricular zone (SVZ) precursors. The project also focuses on the role of glia in the maturation of inhibitory interneurons during postnatal development of the cerebral cortex in mice. Both aspects may offer promising leads to correct or reverse the excitatory and inhibitory neuron imbalances that are present in the cerebral cortex of neuropsychiatric and impulse control disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $399,013.00
Project Number 2R01MH067715-06A1
Principal Investigator Vaccarino, Flora
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 Morphogenesis and function of the cerebral cortex (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Morphogenesis and function of the cerebral cortex | $409,165.00 | 2010 | 5R01MH067715-07