Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Systematic analysis of neural circuitry in mouse models of autism  

Dr. Osten and his colleagues hypothesize that mutations in the heterogeneous autism candidate genes result in more homogeneous core dysfunctions of neural circuitry responsible for the disorder's clinical features. The researchers will search for causal links between genetic variants and neural circuit malfunctions in mouse models of autism. They will screen neural circuits in the brains of 'indicator' mice, in which genes representative of neural activity — such as c-Fos and Arc — are tagged with a green fluorescent protein. A custom-built microscope will be used to capture three-dimensional images of whole mouse brains. The researchers will then use these images to screen and compare neural circuits — indicated by green-lit areas — in autism-model mice and their normal counterparts. Osten and colleagues also hope to facilitate future mouse model work by focusing the autism research community's attention on the most promising areas of the brain. Project Status


Funder Simons Foundation
Fiscal Year Funding $75,431.50
Project Number 137480
Principal Investigator Osten, Pavel
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Cold Spring Harbor Laboratory
State/Country New York
Web Link 1 Systematic analysis of neural circuitry in mouse models of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Systematic analysis of neural circuitry in mouse models of autism | $149,972.50 | 2010 | 137480