Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Dynamic regulation of Shank3 and ASD  

Mutations in the Shank3 gene have been identified in multiple cases of autism spectrum disorder (ASD); however, it is not yet known how these mutations produce disease. Shank3 is a scaffolding protein that interacts with several glutamate receptors and other receptor associated proteins and appears to play a role in coordinating physiological interactions between these receptors at excitatory synapses. To explore the molecular basis of ASD, these studies will examine two new mouse genetic models to evaluate how mutations of Shank3 alter synaptic function and behavior. Project Status


Funder National Institutes of Health
Fiscal Year Funding $300,000.00
Project Number 1R01NS070301-01
Principal Investigator Worley, Paul
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Johns Hopkins University
State/Country Maryland
Web Link 1 Dynamic regulation of Shank3 and ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Dynamic regulation of Shank3 and ASD | $300,000.00 | 2010 | 5R01NS070301-02