Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Central vasopressin receptors and affiliation  

Autism spectrum disorders (ASDs) are characterized by deficits in three core domains: social interaction, communication, and repetitive behaviors. Recent data suggests that while all three behavioral domains are highly heritable, separate genes may contribute independently to variation in each domain. This proposal focuses on the role of the vasopressin V1a receptor (V1aR) in generating diversity in social behaviors in an animal model (prairie voles) and humans. The V1aR plays a critical regulatory role in several behaviors in the social domain, including social recognition, parental care, and social bonding. The study will examine variations in expression of the AVPR1A gene (which encodes the V1aR), look for polymorphisms (changes in DNA sequence), and determine the gene's role in variation in social behavior of prairie voles. Correlations between polymorphic sites near the AVPR1A gene and phenotypic behavioral measures will then be examined in human subjects. Results from these studies will provide important information on the relationship of variation in the V1aR system and social behavior and may lead to therapies specifically targeting the social deficits in autism. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $363,959.00
Project Number 5R01MH056897-13
Principal Investigator Young, Larry
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 Central vasopressin receptors and affiliation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Central vasopressin receptors and affiliation | $364,425.00 | 2010 | 5R01MH056897-14
Central vasopressin receptors and affiliation | $364,358.00 | 2008 | R01MH056897-12