Prairie voles are ideally suited for investigating the mechanisms underlying variation in social behavior because of the behavioral diversity between different species of prairie voles as well as intra-species diversity. This provides the opportunity to discover novel genes contributing to the regulation and diversity of social behavior. The discoveries made in prairie voles have important implications for psychiatric disorders associated with impairments in social behavior, including autism, schizophrenia, and depression. This proposal will develop two genomic resources for the prairie vole that will enhance the value of this species as a model for understanding the genetic and neurobiological mechanisms governing social behavior. First, a microsatellite-based genetic linkage map of the prairie vole genome that can be used in Quantitative Trait Locus (QTL) studies will be constructed. A bacterial artificial chromosome (BAC) library of the prairie vole genome will also be created to isolate clones containing several genes of interest to the prairie vole research community. Used together, these resources will facilitate the discovery of novel genes involved in the regulation of social behavior and will be made freely available to the research community.