Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Development of genomic resources for prairie voles  

Prairie voles are ideally suited for investigating the mechanisms underlying variation in social behavior because of the behavioral diversity between different species of prairie voles as well as intra-species diversity. This provides the opportunity to discover novel genes contributing to the regulation and diversity of social behavior. The discoveries made in prairie voles have important implications for psychiatric disorders associated with impairments in social behavior, including autism, schizophrenia, and depression. This proposal will develop two genomic resources for the prairie vole that will enhance the value of this species as a model for understanding the genetic and neurobiological mechanisms governing social behavior. First, a microsatellite-based genetic linkage map of the prairie vole genome that can be used in Quantitative Trait Locus (QTL) studies will be constructed. A bacterial artificial chromosome (BAC) library of the prairie vole genome will also be created to isolate clones containing several genes of interest to the prairie vole research community. Used together, these resources will facilitate the discovery of novel genes involved in the regulation of social behavior and will be made freely available to the research community. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $158,400.00
Project Number 5R21MH082225-02
Principal Investigator Young, Larry
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 Development of genomic resources for prairie voles (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Development of genomic resources for prairie voles | $277,200.00 | 2008 | R21MH082225-01A1