Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Identifying autism susceptibility genes by high-throughput chip resequencing  

The goal of this project is to identify mutations leading to a diagnosis of autism. The study will use high-throughput microarray-based DNA chips to resequence genes in 314 male affected sibling pairs (from the Autism Genome Research Exchange (AGRE) sample collection) that may harbor mutations that cause autism. Specifically, the gene regions that will be resequenced are the FMR1 gene associated with fragile X syndrome and another region on the X chromosome that has shown linkage to autism susceptibility. Identifying the genetic basis of autism could enable more rapid diagnostic testing and provide insight into the root causes and eventually pave the way for better treatments of this increasingly common disorder. Project Status


Funder National Institutes of Health
Fiscal Year Funding $447,043.00
Project Number 5R01MH076439-05
Principal Investigator Zwick, Michael
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution Emory University
State/Country Georgia
Web Link 1 Identifying autism susceptibility genes by high-throughput chip resequencing (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Identifying autism susceptibility genes by high-throughput chip resequencing | $519,565.00 | 2008 | R01MH076439-04