Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neurophysiological investigation of language acquisition in infants at risk for ASD  

Although language impairment is common is ASD, it is unclear at what point language acquisition in individuals with ASD begins to diverge from the typical trajectory. Recent developmental studies of ASD suggest that impairment in language and other domains may be present by 12 months (Mitchell, et al., 2006), but behavioral measures have failed to find consistent deficits before this age. Neurophysiological measures, which can be more sensitive to dysfunction before 12 months, have not yet been used to study very early language processing in ASD. The current project will study auditory ERP longitudinally in infants at risk for developing ASD (HRA) or language impairment (HRL) along with low risk controls (LRC). Our preliminary work suggests that HRA infants fail to develop lateralized ERP response to speech stimuli at 9 and 12 months. Here, we will examine whether this atypical asymmetry persists over the second and third years of life and whether it is predictive of later symptoms of ASD or SLI. Additionally, we will use ERP to examine phonemic perceptual narrowing between 6 and 12 months to determine whether this is delayed in infants who are later diagnosed with ASD and whether it is predictive of later language ability in HRA infants as it is in typical development. Finally, we will examine whether atypical ERP response to speech between 6 and 12 months may act as a neurobiological risk marker for ASD diagnosis, helping us to detect ASD over the first year of life. Project Status


Funder Autism Speaks
Fiscal Year Funding $28,000.00
Current Award Period 2010-2012
Project Number 7003
Principal Investigator Seery, Anne
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Early Signs and Biomarkers
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Federal or Private? Private
Institution Boston University
State/Country Massachusetts
Web Link 1 Neurophysiological investigation of language acquisition in infants at risk for ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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