Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Clinical Phenotype: Recruitment and Assessment Core  

This grant provides support for an NIH Autism Center of Excellence (ACE). This ACE aims to discover the mechanisms related to early brain overgrowth in autism and to define specific behavioral and biological factors associated with infants at-risk for the disorder. The Clinical Phenotype: Recruitment and Assessment Core (CPRAC) will implement a strategy called the 1-Year Well-Baby Check-Up Approach to identify and study infants at risk for an autism spectrum disorder (ASD) prospectively. This unbiased approach will identify ASD cases from both singleton and multiplex families, and the CPRAC will recruit a total of 3 study groups: at-risk ASD, at-risk developmental disability, and typically developing. The CPRAC will be responsible for: 1) identification and recruitment of 12-month old infants, 2) medical and behavioral diagnostic and psychometric evaluations of study infants every 6 months, 3) coordination of each infant's participation in magnetic resonance imaging (MRI), functional MRI, and genetic studies, and 4) final diagnoses when each participant turns three. Project Status


Funder National Institutes of Health
Fiscal Year Funding $361,993.00
Current Award Period 2007-2012
Project Number 5P50MH081755-04
Principal Investigator Pierce, Karen
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Early Signs and Biomarkers
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 ACE Center: Clinical Phenotype: Recruitment and Assessment Core (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects ACE Center: Clinical Phenotype: Recruitment and Assessment Core | $393,095.00 | 2009 | 5P50MH081755-03