Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Integrated Biostatistical and Bioinformatic Analysis Core (IBBAC)  

This grant provides support for an NIH Autism Center of Excellence (ACE). The goal of the University of California, San Diego ACE Integrated Biostatistics and Bioinformatics Analysis Core (IBBAC) is to provide analysis tools, data analyses, and access to state-of-the-field tools, expertise, and leadership for the integrated or combined analysis of data arising from the Clinical Phenotype: Recruitment and Clinical Assessment and Clinical Phenotype: Treatment Response Cores as well as the four proposed projects. The ultimate aim of this research is to identify a unique set of clinical, subclinical (e.g., imaging-based phenotypes), and genomic endpoints (or "fingerprints") that are correlated with autism spectrum disorder (ASD) and/or developmental delay (DD) and are distinct from features found in typically-developing children. Although there is considerable research in the development of mathematical models of multiparameter biological processes (e.g., gene transcription) as well as data mining/pattern discovery strategies for genomic technologies, there is less research on, and actual implementation of, the development of hypothesis-oriented multivariate data analysis methodologies that consider the information produced by genomic and multiplex phenotyping technologies either in isolation or in combination. The proposed IBBAC activity will consider the development, deployment, and interpretation of novel multivariate analysis methods appropriate for drawing meaningful inferences from the high-dimensional genomic and phenotypic data generated as part of the proposed UCSD ACE research. Project Status


Funder National Institutes of Health
Fiscal Year Funding $208,661.00
Current Award Period 2007-2012
Project Number 5P50MH081755-04
Principal Investigator Schork, Nicholas
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Early Signs and Biomarkers
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 ACE Center: Integrated Biostatistical and Bioinformatic Analysis Core (IBBAC) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects ACE Center: Integrated Biostatistical and Bioinformatic Analysis Core (IBBAC) | $202,457.00 | 2009 | 5P50MH081755-03