Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Magnetic source imaging and sensory behavioral characterization in autism  

The purpose of this mentored Research Career Development Award is to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research. In this study, the trainee will use advanced brain imaging techniques to reliably measure the temporal, spatial, and frequency characteristics of neural activity in children with autism during sensory perception. The goal of this study is to ascertain whether individuals with autism show hyper-excitation in specific brain regions and whether such hyper-excitation directly correlates with behaviorally observed sensory over-reactivity, like sensitivity to touch and sound. This cross-sectional case-control study will assess sensory processing in boys (9-11 years) with autism and a performance IQ >70 relative to matched healthy controls. Diagnostic evaluation, cognitive testing, objective sensory assessment, magnetoencephalography (MEG), and magnetic resonance imaging (MRI) will be conducted on 20 children with autism and 20 healthy controls. Long term research goals include using magnetic source imaging (MSI) to: (1) probe the etiology of autism, (2) facilitate early accurate diagnosis, and (3) create an objective measure of cognitive processing for use in treatment trials. This project will contribute to the understanding of autism and to the development of diagnostic and treatment studies for the future. Project Status


Funder National Institutes of Health
Fiscal Year Funding $176,229.00
Current Award Period 2008-2012
Project Number 5K23MH083890-03
Principal Investigator Marco, Elysa
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Early Signs and Biomarkers
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Federal or Private? Federal
Institution University of California, San Francisco
State/Country California
Web Link 1 Magnetic source imaging and sensory behavioral characterization in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Magnetic source imaging and sensory behavioral characterization in autism | $176,201.00 | 2009 | 5K23MH083890-02
Magnetic source imaging and sensory behavioral characterization in autism | $166,302.00 | 2008 | K23MH083890-01