Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Developmental social neuroscience in infants at-risk for autism  

This is a mentored Research Career Development Award to support the career development of clinical investigators in patient-oriented research. This project will study the brain mechanisms involved in perceiving social information, thought to be impaired in people with autism. Brain activity and visual attention will be used to measure processing of social information in infants who are at increased risk for autism. The research will entail a longitudinal study of 60 infants at-risk for autism spectrum disorder (ASD) and 40 low-risk infants. Three experiments will be administered at 4 time points (6, 12, 18, and 24 months) to contrast social and non-social perception using static visual stimuli (mother/stranger face versus familiar/unfamiliar object), auditory stimuli (mother/stranger voice versus non-speech analogs), and dynamic audio-visual stimuli (naturalistic video clips of mother/stranger speaking versus non-biological motion and sounds). These experimental probes will map behavioral and brain specialization for social information in infancy in typical and atypical development. This research will elucidate early brain dysfunction in ASD for earlier detection and more effective intervention. Project Status


Funder National Institutes of Health
Fiscal Year Funding $180,659.00
Current Award Period 2010-2014
Project Number 1K23MH086785-01A1
Principal Investigator McPartland, James
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Subcategory Early Signs and Biomarkers
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 1LC. Identify and develop measures to assess at least three "continuous dimensions" (i.e., social reciprocity, communication disorders, and repetitive/restrictive behaviors) of ASD symptoms and severity that can be used by practitioners and/or families to assess response to intervention for people with ASD across the lifespan by 2016. IACC Recommended Budget: $18,500,000 over 5 years.
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 Developmental social neuroscience in infants at-risk for autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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