Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The effects of Npas4 and Sema4D on inhibitory synapse formation  

Dr. Greenberg and colleagues have identified an activity-regulated gene, Npas4, that encodes a protein required specifically for the formation of inhibitory synapses. However, the molecular mechanism by which Npas4 selectively controls the formation of inhibitory synapses remains unknown. This project will use mice deficient in Npas4 to gain insight into this process. Genome-wide screens will also be carried out to identify the genetic program that Npas4 regulates to promote inhibitory synapse formation. Special attention will be given to those genes that map to regions implicated in autism spectrum disorders (ASD) by human linkage and association studies, as they will be considered ASD candidate genes. The researchers hope to gain insights into the experience-dependent molecular processes responsible for ASD and ultimately uncover therapies and cures for this devastating disease Project Status


Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2007-2010
Project Number 1952
Principal Investigator Greenberg, Michael
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 The effects of Npas4 and Sema4D on inhibitory synapse formation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects The effects of Npas4 and Sema4D on inhibitory synapse formation | $127,500.00 | 2009 | 1952
The effects of Npas4 and Sema4d on inhibitory synapse formation | $150,000.00 | 2008 | 1952