Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Role of Pam in synaptic morphology and function  

The central hypothesis of this proposal is that Pam (Protein Associated with Myc) functions as an E3 ubiquitin ligase and controls the balance of synaptic proteins. The synapse, a basic unit of function in the nervous system, is the primary site of communication between neurons. Aberrant expression of Pam could perturb this balance resulting in excess or reduced neuronal connectivity. Mutations in another E3 ligase have been reported in autism associated with Angelman's syndrome. These observations, as well as the link between tuberous sclerosis complex (TSC) and autism, strongly support the hypothesis that Pam could be a potential player in autism spectrum disorders (ASD). This project is devoted to understanding the role of Pam in mammalian synapses as well as generating an animal model to serve as a valuable model for understanding how synaptic activity may be regulated in ASD. Project Status


Funder Autism Speaks
Fiscal Year Funding $127,497.00
Current Award Period 2007-2010
Project Number 1862
Principal Investigator Ramesh, Vijaya
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Massachusetts General Hospital
State/Country Massachusetts
Web Link 1 Role of Pam in synaptic morphology and function (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Role of Pam in synaptic morphology and function | $127,497.00 | 2009 | 1862
Role of Pam in synaptic morphology and function | $150,000.00 | 2008 | 1862