Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Role of neuroligin in synapse stability  

This proposal will analyze the molecular genetics and cell biology of neuroligin and its role in synapse maintenance in the nematode C. elegans. Using this simple model system, the researchers will be addressing basic issues about the function of neuroligin in the development of the nervous system. Specifically they will study how synapses are impacted by the absence of neuroligin, what other molecules function with neuroligin to regulate synapse stability, and whether adding back neuroligin to the adult organism can rescue the abnormal development which occurred in its absence. Project Status


Funder Autism Speaks
Fiscal Year Funding $127,500.00
Current Award Period 2007-2010
Project Number 1975
Principal Investigator Rand, James
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Oklahoma Medical Research Foundation
State/Country Oklahoma
Web Link 1 Role of neuroligin in synapse stability (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Role of neuroligin in synapse stability | $127,500.00 | 2009 | 1975
Role of neuroligin in synapse stability | $150,000.00 | 2008 | 1975