Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Olivocerebellar circuitry in autism  

Autism is a developmental disorder and affected individuals have alterations in brain function disrupting their ability to perform particular motor and cognitive tasks. The main long term objective of this project is to determine in one major affected brain region, the cerebellum, how synaptic connectivity is disturbed in autism. This post-mortem study will conduct quantitative measures of important synaptic proteins (i.e., glutamatergic transporters and receptors) and relate these measures to the subjects' scores from the Autism Diagnostic Interview-Revised (ADI-R) for reciprocal social interaction, communication, and stereotyped and repetitive motor behavior domains. Data from these studies will help identify core neural substrates that may underlie specific behavioral challenges in autistic individuals and should help guide geneticists in their search for possible candidate genes in the disorder, as well as contribute to understanding current pharmacotherapeutic treatments of autism and develop new treatments targeted to neural substrates. Project Status


Funder National Institutes of Health
Fiscal Year Funding $756,917.00
Current Award Period 2009-2012
Project Number 5R01HD039459-06
Principal Investigator Blatt, Gene
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neuropathology
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Boston University Medical Campus
State/Country Massachusetts
Web Link 1 Olivocerebellar circuitry in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Olivocerebellar circuitry in autism | $756,843.00 | 2009 | 2R01HD039459-05A1