Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Connectivity of anterior cingulate cortex networks in autism  

Autism is increasingly understood as a disconnection syndrome, where an under-connectivity between certain brain regions could underlie social and cognitive deficits. The researchers will apply a novel brain imaging approach to better understand the brain mechanisms and interconnectedness of brain regions involved in autism. Using resting state blood-oxygenation level-dependent functional magnetic resonance imaging (fMRI), the researchers will image two brain networks that in neurotypical controls are commonly associated with social and cognitive control skills, both of which are thought to be disrupted in individuals with autism. Thirty adult males with high-functioning autism will be compared their to 30 matched neurotypical volunteers. Measures of functional connectivity will be correlated with performance on behavioral tasks using the Social Responsiveness Scale and the Behavioral Response Inventory of Executive Functions. The proposed work introduces new techniques for the study of brain circuits in autism and has the potential to further inform the understanding of the neural basis of autism so that improved methods of diagnosis and treatment can be developed. Project Status


Funder National Institutes of Health
Fiscal Year Funding $128,739.00
Current Award Period 2009-2011
Project Number 5R21MH084126-02
Principal Investigator Di Martino, Adriana
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Neural Systems
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution New York University School of Medicine
State/Country New York
Web Link 1 Connectivity of anterior cingulate cortex networks in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Connectivity of anterior cingulate cortex networks in autism | $265,044.00 | 2009 | 1R21MH084126-01A1