Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

GABAergic dysfunction in autism  

The central hypothesis of this project is that certain gene families involved in cell growth and migration and GABAergic neurotransmission will be altered in autism. Specifically, the proteins Reelin and GAD 65 and 67 will be studied. For each protein, the mRNA and protein expression levels of the protein, its receptors, and downstream molecules in the signaling system will be determined in cerebellar, hippocampal, and frontal cortices of autistic subjects and matched controls. The results are expected to demonstrate that gene and protein alterations in brains of autistics involve GABAergic markers, Reelin, and its downstream components, thereby linking GABAergic dysfunction to autistic brain structural abnormalities. Such outcomes will be significant because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $290,090.00
Current Award Period 2007-2012
Project Number 5R01HD052074-04
Principal Investigator Fatemi, Seyyed
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Molecular Pathways
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Minnesota
State/Country Minnesota
Web Link 1 GABAergic dysfunction in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects GABAergic dysfunction in autism | $294,344.00 | 2009 | 5R01HD052074-03
GABAergic dysfunction in autism | $294,333.00 | 2008 | R01HD052074-02
GABAergic dysfunction in autism (supplement) | $63,950.00 | 2009 | 3R01HD052074-03S1